Fabrication of zolmitriptan nasal gel was aimed to get better absorption and patient compliance. Nasal route of administration would also thwart the pre systemic metabolism thus mounting the bioavailability of the drugs. In the present study various formulations were prepared by using gellan gum as gelling agent and mixture of HPMC K 100 and carbopol 940 as controlled or sustained release polymer. Zolmitriptan, 4S-4-({3-[2-(dimethylamino) ethyl]-1H-indol-5-yl} methyl)-1, 3-oxazolidin -2- one, is a second –generation triptan prescribed for patients with migraine attack. All the formulations were investigated for various parameters like pH, viscosity, drug content, gel strength, mucoadhesive strength and release of active pharmaceutical excipient. At least amount of polymer mislay their integrity and at highest concentration stiff gel were formed. At optimized concentration of gelling agent and PVP K25 showed in-situ gelling with all parameter in range. In-vitro release data exposed that the optimized formulation showed controlled and sustained release pattern.
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